Unique, Novel Tumor-Specific Biomarker

Our lead clinical stage natural killer (NK) cell therapy, is an autologous platform technology that activates NK cells to kill cancers expressing a unique membrane form of Heat Shock Protein 70 (mHsp70).

Heat shock protein 70 (Hsp70) is a chaperone protein produced intracellularly by cells in response to exposure to stressful physiological conditions. Hsp70 has been discovered to be highly expressed on the cell membrane (mHsp70) of a variety of different cancer types, but not on the surface of normal cells.

 Metastatic cancers, which are responsible for ~90% of all cancer related deaths, and therapy-resistant disease express the highest levels of membrane Hsp70. Radiation and chemotherapy increases mHsp70 expression and renders tumors more sensitive to therapeutics targeting mHsp70.