AP-401™ is a novel Induced Pluripotent Stem Cell (iPSC) Bi-Specific CAR NK cell targeting CD155 and CD73 which has shown promising efficacy to solid tumors in animal studies.
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CD155, one of the main ligands of TIGIT, is found to be up-regulated in a variety of human malignancies and plays a carcinogenic role by affecting biological functions. The normal cell function of CD155 is to serve as an adhesion molecule and a recognition molecule for natural killer (NK) cells.
CD73 can act as an immune inhibitory control molecule and accumulating studies have shown it to be a key regulatory molecule involved in cancer cell proliferation, migration and invasion in vitro, as well as tumor angiogenesis and tumor immune escape in vivo.