AP-401™ iPSC-Derived Bi-Specific CAR NK Cells

AP-401™ iPSC-Derived Bi-Specific CAR NK Cells

AP-401™ iPSC-Derived Bi-Specific CAR NK Cells

AP-401™, a novel Induced Pluripotent Stem Cell (iPSC) Bi-Specific NK CAR targeting CD155 and an undisclosed target has shown promising efficacy to solid tumors in animal studies.

CD155, one of the main ligands of TIGIT, is found to be up-regulated in a variety of human malignancies and plays a carcinogenic role by affecting biological functions. The normal cell function of CD155 is to serve as an adhesion molecule and a recognition molecule for natural killer (NK) cells.