An allogenic NK cell therapy that targets tumors expressing mHsp70. For this, NK cells are expanded from peripheral blood mononuclear cells (PBMCs) obtained from healthy donors are incubated ex vivo with TKD and IL-2, after which they are frozen, to be thawed prior to intravenous administration to patients.
- Pre-clinical (animal) studies in Germany have demonstrated that TKD/IL-2 activated human allogeneic NK cells control the growth of human metastatic colorectal cancer, NSCLC, and metastatic pancreatic cancer in immune deficient mice. Pre-clinical studies in immune deficient mice have also shown the efficacy of ANKASTIM™ against human metastatic lung cancer to be further improved when combined with OPDIVO®.
- Planned Phase I clinical combination trial in patients with metastatic gastric and colorectal cancer (Stage IV) in the United States, after standard of care (SOC) combined with PD-(L)1 checkpoint inhibitor patients, who failed chemo-radiation and PD-(L)1 checkpoint inhibitors as salvage therapy.